Electrostatics of the KcsA Channel

Continuum electrostatics calculations based on the finite-difference Poisson-Boltzman equation are used to show that the cavity and the pore helices of the KcsA channel are "tuned" to be preferably occupied by a monovalent cation.

B. ROUX and R. MacKinnon, "The cavity and pores helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations", Science 285, 100-102 (1999). [ PubMed ]

Perspective by Bojan Zagrovic and Richard Aldrich "For the Latest Information, Tune to Channel KcsA"